Cardiovascular Danger That Grows Over Time
Several detrans men who took estrogen for years say the biggest shock was how sharply clotting risk rises the longer you stay on it. “The risks spike at a 7-year mark and it’s quite dramatic,” warns ConnectPen, who adds that males on estrogen run an even higher stroke and heart-attack risk than biological females because the male body lacks the protective chemistry women have [citation:7df3632b-cc34-4f97-8f0c-4d450fb8753b]. Drgypsy, a detrans physician, confirms that males on estrogen face “higher risk of strokes and other blood-clotting events than bio-females” and notes that we have never before had so many young males in this experiment [citation:bad77b88-754e-4dc7-be69-beb2f29cac5f].

Permanent Changes That Can’t Be Undone
People who detransition after long-term estrogen report irreversible breast growth, sexual dysfunction, and testicular atrophy. “You’ll probably feel better on E. But then you won’t. And by that time the damage might be permanent—impotence, no sex drive, testicular atrophy, cancers, heart disease,” writes GCMadamXX, who watched the same happen to a family member [citation:17c8ab54-13e8-4809-b752-7aeb1001e981]. HeavenlyMelody91 adds that once breast buds form, the cancer risk is lifelong, because “you still won’t have the protective functions the female body has” [citation:42d29ad3-e378-45b9-89b8-5b57f0f90357].

Auto-immune and Metabolic Surprises
Because large numbers of males have only recently begun taking estrogen, new problems are surfacing. Drgypsy points out that rheumatoid arthritis is now appearing in this young cohort, something rarely seen before in this age group [citation:bad77b88-754e-4dc7-be69-beb2f29cac5f]. ValiMeyer reminds us that earlier “miracle” hormone treatments—thalidomide, menopausal estrogen, fen-phen—looked safe until long-term data proved otherwise, and fears the same may happen here [citation:48ecac00-85d5-47a5-9087-35af437c91fc].

A Generation Still Waiting for Answers
Everyone quoted stresses that the group born 1995-2015 is the first to start these drugs in adolescence, so decades of data simply do not exist. “There is no data. This is a massive experiment,” says Drgypsy, urging anyone considering hormones to wait until at least age 26, when many feelings of dysphoria naturally ease [citation:bad77b88-754e-4dc7-be69-beb2f29cac5f].

Hope Without Hormones
Taken together, these accounts paint a sobering picture: long-term estrogen can permanently alter a male body and raise serious, sometimes life-threatening risks that grow with each passing year. The good news is that psychological support, therapy, and time itself help many people feel at home in their bodies without ever needing to take cross-sex hormones. Choosing gender non-conformity—living freely without drugs—lets you stay healthy while you explore who you really are.